The role for runt related transcription factor 2 (RUNX2) as a transcriptional repressor in luteinizing granulosa cells
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چکیده
منابع مشابه
A role of insulin-like growth factor I in luteinizing hormone receptor expression in granulosa cells.
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Although runt-related transcription factor 2 (RUNX2) is known to be an essential key transcription factor for osteoblast differentiation and bone formation, RUNX2 also plays a pivotal role in the regulation of p53-dependent DNA damage response. In the present study, we report that, in addition to p53, RUNX2 downregulates pro-apoptotic TAp73 during DNA damage-dependent cell death. Upon adriamyci...
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A good model system to examine aspects of positive and negative transcriptional regulation is the muscle-specific regulatory factor, MyoD, which is a basic helix-loop-helix (bHLH) transcription factor. Although MyoD has the ability to induce skeletal muscle terminal differentiation in a variety of non-muscle cell types, MyoD activity itself is highly regulated through protein-protein interactio...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2012
ISSN: 0303-7207
DOI: 10.1016/j.mce.2012.06.005